Pr. Gagnon's research group specializes in the fields of organic synthesis, methodology, catalysis, medicinal chemistry, epigenetics and organometallic chemistry. We are developing reactions catalyzed by transition metals such as copper and palladium and involving reagents called organobismuths. In the field of medicinal chemistry, we are developing inhibitors of biological targets involved in the expression of genes that play a role in the development of diseases such as cancer. More specifically, we are targeting DNA methyltransferases (DNMTs), transcription factors and epigenetic readers (readers).
NOTE: I am currently at Apigenex in Prague. I am therefore not taking any new students nor any new academic administrative tasks.
Pr. Alexandre Gagnon
Alexandre Gagnon, Ph.D.
Full Professor, Chemistry
Université du Québec à Montréal (UQAM)
Department of chemistry
Bureau: CB-3660, Lab: CB-3450
Case Postale 8888, Succ. Centre-Ville,
Canada, H3C 3P8
Téléphone: 1.514.987.3000 ext 6856
Functional group transformation, organic reactions, amino acids, peptides, heterocycles
DNA methyltransferase inhibitors, bromodomain inhibitors, inhibitors of transcription factors
Synthesis of trivalent and pentavalent organobismuths, use in the formation of C–C,
C–O, C–N and C–S bonds
Development of inhibitors of transcription factor YAP–TEAD, Hippo pathway
Transition metal-catalyzed reactions, copper, palladium, optimization of reaction conditions, ligands, organometallic chemistry
Arylation of amino acids, tryptophan, tyrisone
Carbonylative cross-coupling reactions
Hit-to-lead, lead optimization, rational design, docking studies, SAR studies